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Observe Carefully (3)pentobarbital will decrease the extent or outcome of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Potent or average CYP3A4 inducers might raise charge of diazepam elimination; as a result, efficacy of diazepam could possibly be lessened.pentobarbital will reduce the e